Team-based learning (TBL) is a popular form of collaborative learning designed to increase student engagement and motivate students to learn. A growing body of research, particularly in the health sciences, has demonstrated that TBL has positive impacts on student performance and classroom dynamics. However, much less is known about the student outcomes associated with TBL courses in undergraduate science, technology, engineering, and mathematics (STEM) education, fields in which active learning is especially important for student success and retention. To address this gap, we conducted a systematic review of the student outcomes associated with TBL in undergraduate STEM education. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method, we identified 55 empirical and qualitative research articles published between 2005 and 2024 that reported on TBL implementation practices and student outcomes. Importantly, we found that most studies described increased student performance and improved measures of classroom dynamics when TBL was compared to lecture-based teaching approaches. These findings provide further evidence that TBL is an effective instructional method and suggest that TBL can be implemented successfully across a wide range of student populations and undergraduate STEM disciplines.