Artificial Intelligence (AI) is reshaping education across the Asia-Pacific, yet its integration depends on teachers’ readiness and perspectives. This study explores AI adoption among Vietnamese teachers, a critical lens for the region’s digital education reforms, using the Unified Theory of Acceptance and Use of Technology (UTAUT). Through Structural Equation Modeling (SEM) and Latent Dirichlet Allocation (LDA), we analyzed responses from 246 teachers nationwide. Results show attitude strongly predicts adoption intention, with privacy and ethical concerns shaping acceptance, though fears of AI dependence hinder uptake. Uniform challenges across urban-rural and STEM-non-STEM contexts suggest systemic barriers in Vietnam’s education system. Teachers foresee AI as a pedagogical assistant but highlight insufficient training and privacy risks as key obstacles. These findings underscore the need for Asia-Pacific-relevant policies—AI literacy programs, ethical governance, and equitable access—to foster sustainable integration. This research informs regional educational policy by offering a Vietnam-centric model for balancing technological innovation with pedagogical integrity, addressing shared challenges in the Asia-Pacific’s digital transformation.